Nonsteroidal anti-inflammatory drug (NSAID) gastropathy is associated with substantial morbidity and mortality, which result in high costs to. By inhibiting prostaglandin synthesis, nonsteroidal anti- inflammatory drugs ( NSAIDs) compromise gastroduode- nal defense mechanism including blood flow . Hence, the alternative hypothesis will be that the increased susceptibility to NSAID gastropathy among the elderly is a result of alterations or reductions in gastric.

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When refering to evidence in academic writing, you should always try to reference the primary original source. Ndaid is usually the journal article where the information was first stated.

In most cases Physiopedia articles are a secondary source and so should not be used as references. Physiopedia articles are best used to find the original sources of information see the references list at the bottom of the article.

If you believe that this Physiopedia article is the primary source for the information you are refering to, you can use the button below to access a related citation statement. These drugs are used to decrease pain gastroparhy inflammation and are often taken by those diagnosed with osteoarthritis and rheumatoid arthritis or other musculoskeletal conditions. NSAID induced gastropathy can result in stomach or duodenal ulcers which may even lead snaid death.

Though these rates are high, most individuals do not know the risk of these medications and continue to take them.

Also, this induced gastropathy goes on asymptomatically until it is too late and has caused further damage of the gastrointestinal tract. Proton pump inhibitor PPI gaxtropathy reduces gastric ulcer and prevents duodenal ulcer [2]. Though PPIs can help with gastric irritation, it is also found that they can induce risk of osteoporosis which often cause hip fractures in elderly patients as well as increase cardiovascular risk due to low serum magnesium levels in the blood.


H2 receptor antagonists are effective in preventing duodenal ulcer but not gastric ulcer.

Current Perspectives in NSAID-Induced Gastropathy

An early finding of anemia may warrant more extensive diagnostic testing such as an endoscopy or radiography in determination of NSAID gastropathy. Hematocrit and hemoglobin levels may also provide information about the extent of bleeding from perforation or hemorrhage. See Tamblyn et al study on high gastropathy diagnostic rates by physicians [6]. Radiography with barium can also detect and diagnose peptic ulcers but is less common than endoscopy.

NSAIDs inhibit the enzyme cyclooxygenase which is a necessary enzyme for the synthesis of prostaglandins from arachidonic acid.

Gadtropathy inhibition of COX allows NSAIDs to have their anti-inflammatory and analgesic properties by blocking proinflammatory prostaglandins, it also blocks prostaglandins that protect the gastrointestinal system.

Prostaglandins in the gastric system help maintain gastric blood flow, increase bicarbonate production, and increase mucus that serves as a protective barrier ggastropathy bacteria colonization and mechanical injury. Decreased blood flow and decreased mucosa decrease the healing ability and leave the stomach more exposed to gaatropathy from pepsin and gastric acid. The function of cyclooxygenase in this process led to the establishment of two COX isoforms: COX-1 is found throughout all tissues of the body whereas COX-2 is in the area gadtropathy inflammation such as in an area of osteoarthritis contributing to the inflammation.

COX-2 inhibitors are associated with fewer upper GI side effects, however, they are not as symptom free as hoped and still place people at risk of gastroduodenal mucosa injury. These medications are discussed below in the medical management section. A potential complication of ulcers left untreated is that the ulcer can perforate through the stomach mucosa and cause ndaid to spread or the ulcer can erode stomach arteries creating a nsajd bleed.

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Therefore, it is essential that health care professionals assess each patient’s risk factors and recommend either discontinued use of an NSAID or inclusion an accompanying cytoprotectant agent in those patients considered high risk. Other treatment options include misoprostol which is a synthetic prostaglandin designed to replace those loss by NSAIDs.


However, misoprotol has a lot of side effects that have proved difficult such as abdominal pain, nausea, and diarrhea [11]. PTs must be aware of risk factors, clinical signs and systems and be aware the patient may be asymptomatic but still have NSAID induced gastropathyand they must take a detailed patient history including medication questions concerning gastropathu NSAIDs, prescription drugs combined with NSAIDs, and changes to medications.

Any patient who presents with new onset of back or shoulder pain, who takes NSAIDs, and who presents with signs and symptoms of a peptic ulcer must be referred to the MD. Peptic ulcers are typically caused by H. Crohn’s Disease is a type of inflammatory bowel disease which causes the gastrointestinal tract to gastrpathy chronically inflammed. Common symptoms of this disease include abdominal pain, diarrhea, blood in the stool and vomiting and can even cause rectal or gastrointestinal bleeding, loss of appetite and liver inflammation.

The most common symptom is heartburn but those with GERD can also have a dry cough, asthma-like symptoms, and trouble swallowing. The relationship between upper gastrointestinal hemorrhage and drug use: COX-2 inhibitors are an option but they are more expensive.

NSAID Gastropathy: A New Understanding | JAMA Internal Medicine | JAMA Network

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