Learn more about Aranesp® (darbepoetin alfa) Prescribing Information, including Boxed WARNINGS · Medication Guide · Instructions for Use: Single- Dose. Created to help patients understand why CKD can cause anemia and help guide them through the steps to managing their health. for patients that begins after treatment with Aranesp ® or other erythropoietin protein drugs. Aranesp pre-filled syringe – Patient Information Leaflet (PIL) by Amgen Ltd. It is possible that the leaflet in your medicine pack may differ from this version.
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It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged.
Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above. The product code s for this leaflet are: Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
What Aranesp is and what it is used for 2. What you need to know before you use Aranesp 3. How to use Aranesp 4.
Possible side effects 5. How to store Aranesp 6. Contents of the medkcation and other information 7. Instructions for injecting with the Aranesp pre-filled syringe. Jedication doctor has given you Aranesp an anti-anaemic to treat your anaemia. Anaemia is when your blood does not contain enough red blood cells and the symptoms may be fatigue, weakness and shortness of breath. Aranesp works in exactly the same way as the natural hormone erythropoietin.
Erythropoietin is produced in your kidneys and encourages your bone marrow to produce more red blood cells. Aranesp is used to treat symptomatic anaemia that is associated with chronic renal failure kidney failure in adults and children. In kidney failure, the kidney does not produce enough medkcation the natural hormone erythropoietin which can often cause anaemia. Because it will take your body some time to make more red blood cells, it will be about four weeks before you notice any effect.
Your normal dialysis routine will not affect the ability of Aranesp to treat your anaemia. Aranesp is used to treat symptomatic anaemia in adult cancer patients with non-bone marrow cancers non-myeloid malignancies who are receiving chemotherapy.
One of the main side effects of chemotherapy is that it stops the bone marrow producing enough blood cells. Towards the end of your chemotherapy course, particularly if you have had a lot of chemotherapy, your red blood cell count may fall making you anaemic.
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. Cyclosporin and tacrolimus medicines which suppress the immune system may be affected by the number of red cells in your blood.
It is important to tell your doctor if you are taking either of these medicines. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. It is not known whether darbepoetin alfa is excreted in human milk.
You must stop breast-feeding if you use Aranesp. This medicinal product contains less than 1 mmol sodium 23 mg per dose, i. Always use this medicine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure. This may vary depending on whether you are an adult or a child. Your doctor may decide that it is best for you medicstion a carer to inject Aranesp.
Your medicarion, nurse or pharmacist will show you how to inject yourself with the pre-filled syringe. Do not try to inject yourself if you have not been trained. Never inject Aranesp into a vein yourself. In order to correct your anaemia, your initial dose of Aranesp per kilogram of your body weight will be either:.
For adult patients not on dialysis, 1.
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Your doctor will take regular blood samples to measure how your anaemia is responding and may adjust your dose huide every four weeks as necessary in emdication to maintain long-term control of your anaemia. If you do not respond adequately to Aranesp, your doctor will check your dose and will inform you if you medicatoon to change doses of Aranesp.
Your blood pressure will also be checked regularly, particularly at the beginning of your treatment. Your doctor may decide to change the way that your injection is given either under the skin or into a vein.
If this changes you will start on the guise dose as you have been receiving and your doctor will take blood samples to make sure that your anaemia is still being managed correctly.
If your doctor has decided to change your treatment from r-HuEPO erythropoietin produced by gene-technology to Aranesp, they atanesp choose whether you should receive your Aranesp injection once weekly or once every two weeks. The route of injection is the same as with r-HuEPO but your doctor will tell you how much you should take, and when, and may adjust your dose if necessary.
Aranesp is given as a single injection, either once a week or once every three weeks, under your skin. Your doctor will take regular blood samples to measure how your anaemia is responding and may adjust your dose as necessary. Your treatment will continue until approximately four weeks after the end of your chemotherapy. Your doctor will tell you exactly when to stop taking Aranesp.
You could have arajesp problems if you use more Aranesp than you need, such as very high blood pressure. You should contact your doctor, nurse or pharmacist if this does happen. If you feel unwell in any way you meication contact your doctor, nurse or pharmacist immediately. If you have forgotten a dose of Aranesp, you should contact your doctor to discuss when you should inject the next dose. The following side effects have been experienced by some patients taking Aranesp:.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.
You can also report side effects directly see details below. By reporting side effects you can help provide more information on the safety of this medicine. Do not use this medicine after the expiry date which is stated on the carton and on the pre-filled syringe label after EXP. The expiry date refers to the last day of that month. Do not use Aranesp if you think it has been frozen. When your syringe has been removed from the refrigerator and left at room temperature for approximately 30 minutes before injection it must either be used within 7 days or disposed of.
Do not use this medicine if you notice the pre-filled syringe contents are cloudy or there are particles in it. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Aranesp is a clear, colourless or slightly pearly solution for injection in a pre-filled syringe. Aranesp is available in packs of 1 or 4 pre-filled syringes.
The syringes are provided either with 1- and 4-pack or without 1-pack a blister-wrapping. Not all pack sizes may be marketed.
For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.
Detailed information on this medicine is available on the European Medicines Agency website: This section contains information on how to give yourself an injection of Aranesp.
It is important that you do not try to give medicaion the injection unless you have received training from your doctor, nurse or pharmacist.
If you have questions about how to inject, please ask your doctor, nurse or pharmacist for assistance. How do you or the person injecting you, use medicaation Aranesp pre-filled syringe?
Your doctor has prescribed an Aranesp pre-filled syringe for injection into the tissue just under the skin. Your doctor, nurse or pharmacist will tell you how much Aranesp you need and how frequently it should be injected. What should I do before I give myself a subcutaneous injection of Aranesp? Remove the pre-filled syringe from the refrigerator. Leave the pre-filled syringe at room temperature for approximately medicatlon minutes.
This will make the injection more comfortable. Do not warm Aranesp in any other way for example, do not warm it in a microwave or in hot water.
Aranesp® (darbepoetin alfa) | For Healthcare Professionals
Additionally, do not leave the syringe exposed to direct sunlight. Do not shake the pre-filled syringe. Do not remove the cap from the syringe until you are ready to inject. Check that it is the correct dose that your doctor has prescribed. Check the expiry date on the pre-filled syringe label EXP. Do not use it if the date has passed the last day of the month shown.
Check the appearance of Aranesp. It must be a clear, colourless or slightly pearly liquid. If it is cloudy or there are particles in it, you must not use it.
Wash your hands thoroughly. Find a comfortable, well-lit, clean surface and put all the equipment you need within reach. To avoid bending the needle, gently pull the cap from the needle without twisting as shown in pictures 1 and 2. Do not touch the needle or push the plunger.
You may notice a small air bubble in the pre-filled syringe.